Anti-AGTRAP Antibody (CAB12178)
- SKU:
- CAB12178
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AGTRAP Antibody |
| 抗体コード: | CAB12178 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 93-152 of human AGTRAP (NP_001035284.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HT-29, U-87MG, BxPC-3, Mouse kidney, Mouse testis, Mouse heart, Rat kidney, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 93-152 of human AGTRAP (NP_001035284.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ILSL LLKP LSCC FVYH MYRE RGGF LGSS QDRS AYQT IDSA EAPA DPFA VPEG RSQD ARGY |
| 遺伝子ID: | 57085 |
| Uniprot: | Q6RW13 |
| セルラーロケーション: | Cytoplasmic vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein |
| 計算された分子量: | 11kDa/16kDa/17kDa |
| 観察された分子量: | 20kDa |
| 同義語: | AGTRAP, ATRAP |
| バックグラウンド: | This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6RW13 |
| NCBI GenInfo Identifier: | 71152303 |
| NCBI Gene ID: | 57085 |
| NCBI Accession: | Q6RW13.1 |
| UniProt Secondary Accession: | Q6RW13,Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9, A8MVQ5 |
| UniProt Related Accession: | Q6RW13 |
| Molecular Weight: | 11,948 Da |
| NCBI Full Name: | Type-1 angiotensin II receptor-associated protein |
| NCBI Synonym Full Names: | angiotensin II receptor associated protein |
| NCBI Official Symbol: | AGTRAP |
| NCBI Official Synonym Symbols: | ATRAP |
| NCBI Protein Information: | type-1 angiotensin II receptor-associated protein |
| UniProt Protein Name: | Type-1 angiotensin II receptor-associated protein |
| UniProt Synonym Protein Names: | AT1 receptor-associated protein |
| Protein Family: | Type-1 angiotensin II receptor-associated protein |
| UniProt Gene Name: | AGTRAP |
| UniProt Entry Name: | ATRAP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AGTRAP antibody (CAB12178) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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