Anti-AGTR1 Antibody (CAB14201)
- SKU:
- CAB14201
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-AGTR1 Antibody |
| 抗体コード: | CAB14201 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human AGTR1 (NP_000676.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human AGTR1 (NP_000676.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FFSW IPHQ IFTF LDVL IQLG IIRD CRIA DIVD TAMP ITIC IAYF NNCL NPLF YGFL GKKF KRYF LQLL KYIP PKAK SHSN LSTK MSTL SYRP SDNV SSST K |
| 遺伝子ID: | 185 |
| Uniprot: | P30556 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 41kDa |
| 観察された分子量: | 45KDa |
| 同義語: | AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R |
| バックグラウンド: | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. |
| UniProt Protein Function: | AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 3q24 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity Disease: Renal Tubular Dysgenesis; Hypertension, Essential |
| NCBI Summary: | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P30556 |
| NCBI GenInfo Identifier: | 231519 |
| NCBI Gene ID: | 185 |
| NCBI Accession: | P30556.1 |
| UniProt Secondary Accession: | P30556,Q13725, Q8TBK4, |
| UniProt Related Accession: | P30556 |
| Molecular Weight: | 41kDa |
| NCBI Full Name: | Type-1 angiotensin II receptor |
| NCBI Synonym Full Names: | angiotensin II receptor, type 1 |
| NCBI Official Symbol: | AGTR1 |
| NCBI Official Synonym Symbols: | AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B |
| NCBI Protein Information: | type-1 angiotensin II receptor; type-1B angiotensin II receptor |
| UniProt Protein Name: | Type-1 angiotensin II receptor |
| UniProt Synonym Protein Names: | AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1 |
| Protein Family: | Type-1 angiotensin II receptor |
| UniProt Gene Name: | AGTR1 |
| UniProt Entry Name: | AGTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AGTR1 antibody (CAB14201) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |