Anti-AFF4 Antibody (CAB4644)
- SKU:
- CAB4644
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AFF4
- Synonyms:
- AF5Q31
- Synonyms:
- CHOPS
- Synonyms:
- MCEF
Frequently bought together:
Description
| 抗体名: | AFF4 Rabbit pAb |
| 抗体コード: | CAB4644 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | AFF4, AF5Q31, CHOPS, MCEF |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1). |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, HeLa, 293T, LO2, MCF7, Mouse pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1). |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNRE DRNV LRMK ERER RNQE IQQG EDAF PPSS PLFA EPYK VTSK EDKL SSRI QSML GNYD EMKD FIGD RSIP KLVA IPKP TVPP SADE KSNP NFFE QRHG GSHQ SSKW TPVG PAPS TSQS QKRS SGLQ SGHS SQRT SAGS SSGT NSSG QRHD RESY NNSG SSSR KKGQ HGSE HSKS RSSS PGKP QAVS SLNS SHSR SHGN DHHS KEHQ RSKS PRDP DANW |
| 遺伝子ID: | 27125 |
| Uniprot: | Q9UHB7 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 38kDa/98kDa/127kDa |
| 観察された分子量: | 150kDa |
| UniProt Protein Function: | MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm; transcription elongation factor complex; mitochondrion; nucleolus; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; spermatid development Disease: Chops Syndrome |
| NCBI Summary: | The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UHB7 |
| NCBI GenInfo Identifier: | 74720814 |
| NCBI Gene ID: | 27125 |
| NCBI Accession: | Q9UHB7.1 |
| UniProt Related Accession: | Q9UHB7 |
| Molecular Weight: | |
| NCBI Full Name: | AF4/FMR2 family member 4 |
| NCBI Synonym Full Names: | AF4/FMR2 family member 4 |
| NCBI Official Symbol: | AFF4 |
| NCBI Official Synonym Symbols: | MCEF; CHOPS; AF5Q31 |
| NCBI Protein Information: | AF4/FMR2 family member 4 |
| UniProt Protein Name: | AF4/FMR2 family member 4 |
| UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein |
| Protein Family: | AF4/FMR2 family |
| UniProt Gene Name: | AFF4 |
| UniProt Entry Name: | AFF4_HUMAN |