Anti-AES Antibody (CAB7874)
- SKU:
- CAB7874
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-AES Antibody |
抗体コード: | CAB7874 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human AES (NP_945320.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | A-549, HeLa, U-251MG, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human AES (NP_945320.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MCHK NGFP QEGG ITAA FLQK RKLR LSKN HRPA RAKV TEHV RGTR PGRA TAGP AAST RAAG SLFF DRWG NRGP AGCR GSSH LPQQ LKFT TSDS CDRI KDEF QLLQ AQYH SLKL ECDK LASE KSEM QRHY VMYY EMSY GLNI EMHK QAEI VKRL NGIC AQVL PYLS QEHQ QQVL GAIE RAKQ VTAP ELNS IIRQ QLQA HQLS QLQA LALP LTPL PVGL QPPS LPAV SAGT GLLS LSAL GSQA HLSK EDKN GHDG DTHQ EDDG EKSD |
遺伝子ID: | 166 |
Uniprot: | Q08117 |
セルラーロケーション: | Nucleus |
計算された分子量: | 21kDa/29kDa |
観察された分子量: | 22kDa |
同義語: | AES, AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5 |
バックグラウンド: | The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | AES: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Belongs to the WD repeat Groucho/TLE family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of growth; multicellular organismal development; cellular response to extracellular stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; skeletal development |
NCBI Summary: | The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q08117 |
NCBI GenInfo Identifier: | 23503062 |
NCBI Gene ID: | 166 |
NCBI Accession: | Q08117.4 |
UniProt Secondary Accession: | Q08117,Q12808, Q14CJ1, Q96TG9, Q9UDY9, B2RBL0, |
UniProt Related Accession: | Q08117 |
Molecular Weight: | 29,091 Da |
NCBI Full Name: | Amino-terminal enhancer of split |
NCBI Synonym Full Names: | amino-terminal enhancer of split |
NCBI Official Symbol: | AES |
NCBI Official Synonym Symbols: | GRG; ESP1; GRG5; TLE5; AES-1; AES-2 |
NCBI Protein Information: | amino-terminal enhancer of split; gp130-associated protein GAM |
UniProt Protein Name: | Amino-terminal enhancer of split |
UniProt Synonym Protein Names: | Gp130-associated protein GAM; Protein ESP1; Protein GRG |
Protein Family: | Acetyl esterase |
UniProt Gene Name: | AES |
UniProt Entry Name: | AES_HUMAN |
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