Anti-ADRA2C Antibody (CAB16956)
- SKU:
- CAB16956
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-ADRA2C Antibody |
| 抗体コード: | CAB16956 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2C (NP_000674.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2C (NP_000674.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RTRT LSEK RAPV GPDG ASPT TENG LGAA AGAG ENGH CAPP PADV EPDE SSAA AERR RRRG ALRR GGRR RAGA EGGA GGAD GQGA GPGA AESG ALTA SRSP GPGG RLSR ASSR SVEF FLSR RRRA RSSV CRRK VAQA REKR F |
| 遺伝子ID: | 152 |
| Uniprot: | P18825 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 50kDa |
 | Western blot - ADRA2C Rabbit pAb (CAB16956) |
| 同義語: | ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, ADRA2C |
| バックグラウンド: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 4p16 Cellular Component: cytoplasm; endosome; integral to plasma membrane; plasma membrane Molecular Function:alpha-2A adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: activation of protein kinase B; cell-cell signaling; G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation; regulation of insulin secretion |
| NCBI Summary: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18825 |
| NCBI GenInfo Identifier: | 20141211 |
| NCBI Gene ID: | 152 |
| NCBI Accession: | P18825.2 |
| UniProt Secondary Accession: | P18825,P35369, Q9HB49, |
| UniProt Related Accession: | P18825 |
| Molecular Weight: | 49,522 Da |
| NCBI Full Name: | Alpha-2C adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor alpha 2C |
| NCBI Official Symbol: | ADRA2C |
| NCBI Official Synonym Symbols: | ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR |
| NCBI Protein Information: | alpha-2C adrenergic receptor |
| UniProt Protein Name: | Alpha-2C adrenergic receptor |
| UniProt Synonym Protein Names: | Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR |
| Protein Family: | Alpha-2C adrenergic receptor |
| UniProt Gene Name: | ADRA2C |
| UniProt Entry Name: | ADA2C_HUMAN |