Anti-ADRA2A Antibody (CAB2809)
- SKU:
- CAB2809
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ADRA2A Antibody |
| 抗体コード: | CAB2809 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | K-562, Mouse brain, Mouse Spinal cord |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RRTR VPPS RRGP DAVA APPG GTER RPNG LGPE RSAG PGGA EAEP LPTQ LNGA PGEP APAG PRDT DALD LEES SSSD HAER PPGP RRPE RGPR GKGK ARAS QVKP GDSL PRRG PGAT GIGT PAAG PGEE RVGA AKAS RWRG R |
| 遺伝子ID: | 150 |
| Uniprot: | P08913 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 49kDa |
| 同義語: | ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 |
| バックグラウンド: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. |
| UniProt Protein Function: | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. |
| NCBI Summary: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08913 |
| NCBI GenInfo Identifier: | 1351829 |
| NCBI Gene ID: | 150 |
| NCBI Accession: | P08913.3 |
| UniProt Secondary Accession: | P08913,Q2I8G2, Q2XN99, Q86TH8, Q9BZK1, B0LPF6, |
| UniProt Related Accession: | P08913 |
| Molecular Weight: | 48,957 Da |
| NCBI Full Name: | Alpha-2A adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor alpha 2A |
| NCBI Official Symbol: | ADRA2A |
| NCBI Official Synonym Symbols: | ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR |
| NCBI Protein Information: | alpha-2A adrenergic receptor |
| UniProt Protein Name: | Alpha-2A adrenergic receptor |
| UniProt Synonym Protein Names: | Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR |
| Protein Family: | Alpha-2A adrenergic receptor |
| UniProt Gene Name: | ADRA2A |
| UniProt Entry Name: | ADA2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADRA2A antibody (CAB2809) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using ADRA2A Rabbit pAb (CAB2809) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using ADRA2A Rabbit pAb (CAB2809) at dilution of 1:100. Blue: DAPI for nuclear staining. |
View AllClose