| バックグラウンド: | Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
| UniProt Protein Function: | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| NCBI Summary: | Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017] |
| UniProt Code: | P35611 |
| NCBI GenInfo Identifier: | 12644231 |
| NCBI Gene ID: | 118 |
| NCBI Accession: | P35611.2 |
| UniProt Secondary Accession: | P35611,Q13734, Q14729, Q16156, Q86XM2, Q9UJB6, A2A3N8 A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, |
| UniProt Related Accession: | P35611 |
| Molecular Weight: | 73,333 Da |
| NCBI Full Name: | Alpha-adducin |
| NCBI Synonym Full Names: | adducin 1 |
| NCBI Official Symbol: | ADD1 |
| NCBI Official Synonym Symbols: | ADDA |
| NCBI Protein Information: | alpha-adducin |
| UniProt Protein Name: | Alpha-adducin |
| UniProt Synonym Protein Names: | Erythrocyte adducin subunit alpha |
| Protein Family: | Alpha-adducin |
| UniProt Gene Name: | ADD1 |
