Anti-ADCK3 Antibody (CAB7378)
- SKU:
- CAB7378
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ADCK3 Antibody |
抗体コード: | CAB7378 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ADCK3 (NP_064632.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse liver, Mouse heart, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ADCK3 (NP_064632.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAI LGDT IMVA KGLV KLTQ AAVE THLQ HLGI GGEL IMAA RALQ STAV EQIG MFLG KVQG QDKH EEYF AENF GGPE GEFH FSVP HAAG ASTD FSSA SAPD QSAP PSLG HAHS EGPA PAYV ASGP FREA GFPG QASS PLGR ANGR LFAN PRDS FSAM GFQR RFFH QDQS PVGG LTAE DIEK ARQA KARP ENKQ HKQT LSEH ARER KVPV TRIG RLAN FGGL |
遺伝子ID: | 56997 |
Uniprot: | Q8NI60 |
セルラーロケーション: | Membrane, Mitochondrion, Single-pass membrane protein |
計算された分子量: | 18kDa/42kDa/66kDa/71kDa |
観察された分子量: | 55kDa |
同義語: | COQ8A, ADCK3, ARCA2, CABC1, COQ10D4, COQ8, SCAR9 |
バックグラウンド: | This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. |
UniProt Protein Function: | ADCK3: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4). An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Belongs to the protein kinase superfamily. ADCK protein kinase family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, atypical; EC 2.7.11.-; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; ABC1 family; ABC1-A subfamily Chromosomal Location of Human Ortholog: 1q42.13 Cellular Component: mitochondrion Molecular Function:protein serine/threonine kinase activity; ATP binding Biological Process: ubiquinone biosynthetic process; protein amino acid phosphorylation Disease: Coenzyme Q10 Deficiency, Primary, 4 |
NCBI Summary: | This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NI60 |
NCBI GenInfo Identifier: | 27923741 |
NCBI Gene ID: | 56997 |
NCBI Accession: | Q8NI60.1 |
UniProt Secondary Accession: | Q8NI60,Q5T7A5, Q63HK0, Q8NCJ6, Q9HBQ1, Q9NQ67, |
UniProt Related Accession: | Q8NI60 |
Molecular Weight: | 647 |
NCBI Full Name: | Chaperone activity of bc1 complex-like, mitochondrial |
NCBI Synonym Full Names: | aarF domain containing kinase 3 |
NCBI Official Symbol: | ADCK3 |
NCBI Official Synonym Symbols: | COQ8; ARCA2; CABC1; SCAR9; COQ10D4 |
NCBI Protein Information: | chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog |
UniProt Protein Name: | Chaperone activity of bc1 complex-like, mitochondrial |
UniProt Synonym Protein Names: | aarF domain-containing protein kinase 3 |
UniProt Gene Name: | ADCK3 |
UniProt Entry Name: | ADCK3_HUMAN |
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