Anti-ADAMTS7 Antibody (CAB17093)
- SKU:
- CAB17093
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-ADAMTS7 Antibody |
抗体コード: | CAB17093 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | SH-SY5Y |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 11173 |
Uniprot: | Q9UKP4 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 200kDa |
同義語: | ADAMTS7, ADAM-TS 7, ADAM-TS7, ADAMTS-7 |
バックグラウンド: | The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. |
UniProt Protein Function: | ADAMTS7: Metalloprotease that may play a role in the degradation of COMP. |
UniProt Protein Details: | Protein type:Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: endoplasmic reticulum lumen Molecular Function:metalloendopeptidase activity; metallopeptidase activity; protein binding Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process |
NCBI Summary: | The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q9UKP4 |
NCBI GenInfo Identifier: | 38683827 |
NCBI Gene ID: | 11173 |
NCBI Accession: | NP_055087.2 |
UniProt Secondary Accession: | Q9UKP4,Q14F51, Q6P7J9, |
UniProt Related Accession: | Q9UKP4 |
Molecular Weight: | 55.12kD |
NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein |
NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 7 |
NCBI Official Symbol: | ADAMTS7 |
NCBI Official Synonym Symbols: | ADAM-TS7; ADAMTS-7; ADAM-TS 7 |
NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 7 |
UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 7 |
UniProt Synonym Protein Names: | COMPase |
Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
UniProt Gene Name: | ADAMTS7 |