Anti-ADAMTS13 Antibody (CAB8482)
- SKU:
- CAB8482
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-ADAMTS13 Antibody |
| 抗体コード: | CAB8482 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human ADAMTS13 (NP_620594.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, LO2, 22Rv1, U-251MG, Mouse liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human ADAMTS13 (NP_620594.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DMQL FGPW GEIV SPSL SPAT SNAG GCRL FINV APHA RIAI HALA TNMG AGTE GANA SYIL IRDT HSLR TTAF HGQQ VLYW ESES SQAE MEFS EGFL KAQA S |
| 遺伝子ID: | 11093 |
| Uniprot: | Q76LX8 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 39kDa/144kDa/147kDa/153kDa |
| 観察された分子量: | 154kDa |
| 同義語: | ADAMTS13, ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP |
| バックグラウンド: | This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Calcium-binding; Secreted, signal peptide; Secreted; Protease; EC 3.4.24.87; Extracellular matrix Chromosomal Location of Human Ortholog: 9q34 Cellular Component: endoplasmic reticulum lumen; proteinaceous extracellular matrix Molecular Function:calcium ion binding; integrin binding; metallopeptidase activity; protein binding; zinc ion binding Biological Process: peptide catabolic process; protein processing; proteolysis Disease: Thrombotic Thrombocytopenic Purpura, Congenital |
| NCBI Summary: | This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q76LX8 |
| NCBI GenInfo Identifier: | 74749836 |
| NCBI Gene ID: | 11093 |
| NCBI Accession: | Q76LX8.1 |
| UniProt Secondary Accession: | Q76LX8,Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3, Q9UGQ1 |
| UniProt Related Accession: | Q76LX8 |
| Molecular Weight: | 39,864 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 13 |
| NCBI Official Symbol: | ADAMTS13 |
| NCBI Official Synonym Symbols: | VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| UniProt Synonym Protein Names: | von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS13 |
| UniProt Entry Name: | ATS13_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADAMTS13 antibody (CAB8482) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of NIH-3T3 cells using Anti-ADAMTS13 Polyclonal Antibody (CAB8482) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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