Anti-ADAM22 Antibody (CAB10030)
- SKU:
- CAB10030
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ADAM22 Antibody |
抗体コード: | CAB10030 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-400 of human ADAM22 (NP_004185.1). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:4000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, Mouse brain, Mouse kidney, Mouse heart, Rat kidney, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-400 of human ADAM22 (NP_004185.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SKRQ LRRY PRNV EEET KYIE LMIV NDHL MFKK HRLS VVHT NTYA KSVV NMAD LIYK DQLK TRIV LVAM ETWA TDNK FAIS ENPL ITLR EFMK YRRD FIKE KSDA VHLF SGSQ FESS RSGA AYIG GICS LLKG GGVN EFGK TDLM AVTL AQSL AHNI GIIS DKRK LASG ECKC EDTW SG |
遺伝子ID: | 53616 |
Uniprot: | Q9P0K1 |
セルラーロケーション: | Cell projection, Membrane, Single-pass type I membrane protein, axon |
計算された分子量: | 91kDa/95kDa/96kDa/100kDa |
観察された分子量: | 100kDa |
同義語: | ADAM22, ADAM 22, MDC2 |
バックグラウンド: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. |
UniProt Protein Function: | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. |
NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010] |
UniProt Code: | Q9P0K1 |
NCBI GenInfo Identifier: | 62204768 |
NCBI Gene ID: | 53616 |
NCBI Accession: | AAH92465.1 |
UniProt Related Accession: | Q9P0K1 |
Molecular Weight: | |
NCBI Full Name: | ADAM22 protein |
NCBI Synonym Full Names: | ADAM metallopeptidase domain 22 |
NCBI Official Symbol: | ADAM22 |
NCBI Official Synonym Symbols: | MDC2; EIEE61; ADAM 22 |
NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 22 |
UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 22 |
UniProt Synonym Protein Names: | Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 |
UniProt Gene Name: | ADAM22 |
View AllClose