| バックグラウンド: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. |
| UniProt Protein Function: | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9P0K1 |
| NCBI GenInfo Identifier: | 62204768 |
| NCBI Gene ID: | 53616 |
| NCBI Accession: | AAH92465.1 |
| UniProt Related Accession: | Q9P0K1 |
| Molecular Weight: | |
| NCBI Full Name: | ADAM22 protein |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 22 |
| NCBI Official Symbol: | ADAM22 |
| NCBI Official Synonym Symbols: | MDC2; EIEE61; ADAM 22 |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 22 |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 22 |
| UniProt Synonym Protein Names: | Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 |
| UniProt Gene Name: | ADAM22 |
