Anti-ADAM11 Antibody (CAB14249)
- SKU:
- CAB14249
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ADAM11 Antibody |
抗体コード: | CAB14249 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human ADAM11 (NP_002381.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human ADAM11 (NP_002381.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | METW ADGD KIQV QDDL LETL ARLM VYRR EGLP EPSD ATHL FSGR TFQS TSSG AAYV GGIC SLSH GGGV NEYG NMGA MAVT LAQT LGQN LGMM WNKH RSSA GDCK CPDI WLGC IMED TGFY LPRK FSRC SIDE YNQF LQEG G |
遺伝子ID: | 4185 |
Uniprot: | O75078 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 57kDa/83kDa |
観察された分子量: | 83kDa |
同義語: | ADAM11, MDC |
バックグラウンド: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
UniProt Protein Function: | ADAM11: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: extracellular matrix; plasma membrane Molecular Function:integrin binding; metallopeptidase activity Biological Process: integrin-mediated signaling pathway |
NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | O75078 |
NCBI GenInfo Identifier: | 115502351 |
NCBI Gene ID: | 4185 |
NCBI Accession: | O75078.3 |
UniProt Secondary Accession: | O75078,Q14808, Q14809, Q14810, |
UniProt Related Accession: | O75078,AAB29191 |
Molecular Weight: | 57,911 Da |
NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 11 |
NCBI Synonym Full Names: | ADAM metallopeptidase domain 11 |
NCBI Official Symbol: | ADAM11 |
NCBI Official Synonym Symbols: | MDC |
NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 11 |
UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 11 |
UniProt Synonym Protein Names: | Metalloproteinase-like, disintegrin-like, and cysteine-rich protein; MDC |
Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
UniProt Gene Name: | ADAM11 |
UniProt Entry Name: | ADA11_HUMAN |
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