Anti-ACTR3 Antibody (CAB1064)
- SKU:
- CAB1064
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ACTR3 Antibody |
| 抗体コード: | CAB1064 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat, Monkey |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human ACTR3 (NP_005712.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse, Rat, Monkey |
| ポジティブサンプル: | K-562, HL-60, HeLa, Jurkat, COS-1, COS-7, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human ACTR3 (NP_005712.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGR LPAC VVDC GTGY TKLG YAGN TEPQ FIIP SCIA IKES AKVG DQAQ RRVM KGVD DLDF FIGD EAIE KPTY ATKW PIRH GIVE DWDL MERF MEQV IFKY LRAE PEDH YFLL TEPP LNTP ENRE YTAE IMFE SFNV PGLY IAVQ AVLA LAAS WTSR QVGE RTLT GTVI DSGD GVTH VIPV AEGY VIGS CIKH IPIA GRDI TYFI QQLL RDRE VGIP PEQS LETA KAVK ERYS YVCP DLVK EFNK YDTD GSKW IKQY TGIN AISK KEFS IDVG YERF LGPE IFFH PEFA NPDF TQPI SEVV DEVI QNCP IDVR RPLY KNIV LSGG STMF RDFG RRLQ RDLK RTVD ARLK LSEE LSGG RLKP KPID VQVI THHM QRYA VWFG GSML ASTP EFYQ VCHT KKDY EEIG PSIC RHNP VFGV MS |
| 遺伝子ID: | 10096 |
| Uniprot: | P61158 |
| セルラーロケーション: | Cell projection, Cytoplasm, cytoskeleton |
| 計算された分子量: | 47kDa |
| 観察された分子量: | 47kDa |
| 同義語: | ACTR3, ARP3 |
| バックグラウンド: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; hemidesmosome; membrane; lamellipodium; excitatory synapse; podosome; actin filament; intercellular junction; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding Biological Process: response to antibiotic; positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; ephrin receptor signaling pathway; innate immune response; cytokinesis after meiosis; positive regulation of dendrite morphogenesis; cell motility; response to carbohydrate stimulus; spindle localization |
| NCBI Summary: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P61158 |
| NCBI GenInfo Identifier: | 47117647 |
| NCBI Gene ID: | 10096 |
| NCBI Accession: | P61158.3 |
| UniProt Secondary Accession: | P61158,P32391, Q53QM2, |
| UniProt Related Accession: | P61158 |
| Molecular Weight: | 47,371 Da |
| NCBI Full Name: | Actin-related protein 3 |
| NCBI Synonym Full Names: | ARP3 actin-related protein 3 homolog (yeast) |
| NCBI Official Symbol: | ACTR3 |
| NCBI Official Synonym Symbols: | ARP3 |
| NCBI Protein Information: | actin-related protein 3; actin-like protein 3 |
| UniProt Protein Name: | Actin-related protein 3 |
| UniProt Synonym Protein Names: | Actin-like protein 3 |
| UniProt Gene Name: | ACTR3 |
| UniProt Entry Name: | ARP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACTR3 antibody (CAB1064) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Immunofluorescence analysis of HeLa cells using ACTR3 antibody (CAB1064). Blue: DAPI for nuclear staining. |
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