Anti-ACPP Antibody (CAB13457)
- SKU:
- CAB13457
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-ACPP Antibody |
| 抗体コード: | CAB13457 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human ACPP (NP_001090.2). |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human ACPP (NP_001090.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LVFR HGDR SPID TFPT DPIK ESSW PQGF GQLT QLGM EQHY ELGE YIRK RYRK FLNE SYKH EQVY IRST DVDR TLMS AMTN LAAL FPPE GVSI WNPI LLWQ PIPV HTVP LSED QLLY LPFR NCPR FQEL ESET LKSE EFQK RLHP YKDF IATL GKLS GLHG QDLF GIWS KVYD PLYC ESVH NFTL PSWA TEDT MTKL RELS ELSL LSLY GIHK QKEK SRLQ GGVL VNEI LNHM KRAT QIPS YKKL IMYS AHDT TVSG LQMA L |
| 遺伝子ID: | 55 |
| Uniprot: | P15309 |
| セルラーロケーション: | Cell membrane, Lysosome membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 40kDa/44kDa/48kDa |
| 観察された分子量: |
| 同義語: | ACPP, 5'-NT, ACP-3, ACP3 |
| バックグラウンド: | This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. |
| UniProt Protein Function: | ACPP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.2; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase; EC 3.1.3.5; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; plasma membrane; integral to membrane; vesicle membrane; intracellular; nucleus; secretory granule; filopodium Molecular Function:5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P15309 |
| NCBI GenInfo Identifier: | 130730 |
| NCBI Gene ID: | 55 |
| NCBI Accession: | P15309.3 |
| UniProt Related Accession: | P15309 |
| Molecular Weight: | |
| NCBI Full Name: | Prostatic acid phosphatase |
| NCBI Synonym Full Names: | acid phosphatase, prostate |
| NCBI Official Symbol: | ACPP |
| NCBI Official Synonym Symbols: | ACP3; 5'-NT; ACP-3 |
| NCBI Protein Information: | prostatic acid phosphatase |
| UniProt Protein Name: | Prostatic acid phosphatase |
| UniProt Synonym Protein Names: | 5'-nucleotidase (EC:3.1.3.5); 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase |
| UniProt Gene Name: | ACPP |
| UniProt Entry Name: | PPAP_HUMAN |
 | Immunohistochemistry of paraffin-embedded human prostate using ACPP antibody (CAB13457) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A431 cells using ACPP antibody (CAB13457) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |