Anti-ACAP1 Antibody (CAB15614)
- SKU:
- CAB15614
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ACAP1 Antibody |
| 抗体コード: | CAB15614 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SIEL VEAE VSEL ETRL EKLL KLGT GLLE SGRH YLAA SRAF VVGI CDLA RLGP PEPM MAEC LEKF TVSL NHKL DSHA ELLD ATQH TLQQ QIQT LVKE GLRG FREA RRDF WRGA ESLE AALT HNAE VPRR RAQE AEEA GAAL RTAR AGYR GRAL DYAL QINV IEDK RKFD IMEF VLRL VEAQ ATHF QQGH EELS RLSQ YRKE LGAQ LHQL VLN |
| 遺伝子ID: | 9744 |
| Uniprot: | Q15027 |
| セルラーロケーション: | |
| 計算された分子量: | 81kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | ACAP1, CENTB1 |
| バックグラウンド: |
| UniProt Protein Function: | CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol. |
| UniProt Protein Details: | Protein type:GAPs, ARF; GAPs; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: membrane Molecular Function:protein binding |
| UniProt Code: | Q15027 |
| NCBI GenInfo Identifier: | 3183210 |
| NCBI Gene ID: | 9744 |
| NCBI Accession: | Q15027.1 |
| UniProt Secondary Accession: | Q15027,Q53XN9, |
| UniProt Related Accession: | Q15027 |
| Molecular Weight: | 81,536 Da |
| NCBI Full Name: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
| NCBI Synonym Full Names: | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
| NCBI Official Symbol: | ACAP1 |
| NCBI Official Synonym Symbols: | CENTB1 |
| NCBI Protein Information: | arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
| UniProt Protein Name: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
| UniProt Synonym Protein Names: | Centaurin-beta-1; Cnt-b1 |
| Protein Family: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein |
| UniProt Gene Name: | ACAP1 |
| UniProt Entry Name: | ACAP1_HUMAN |
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