Anti-ABCG8 Antibody (CAB1880)
- SKU:
- CAB1880
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ABCG8 Antibody |
| 抗体コード: | CAB1880 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human ABCG8 (NP_071882.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | A-549 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human ABCG8 (NP_071882.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGK AAEE RGLP KGAT PQDT SGLQ DRLF SSES DNSL YFTY SGQP NTLE VRDL NYQV DLAS QVPW FEQL AQFK MPWT SPSC QNSC ELGI QNLS FKVR SGQM LAII GSSG CGRA SLLD VITG RGHG GKIK SGQI WING QPSS PQLV RKCV AHVR QHNQ LLPN LTVR ETLA FIAQ MRLP RTFS QAQR DKRV EDVI AELR LRQC ADTR VGNM YVRG LSGG ERRR VSIG VQLL WNPG ILIL DEPT SGLD SFTA HNLV KTLS RLAK GNRL VLIS LHQP RSDI FRLF DLVL LMTS GTPI YLGA AQHM VQYF TAIG YPCP RYSN PADF |
| 遺伝子ID: | 64241 |
| Uniprot: | Q9H221 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 75kDa |
| 観察された分子量: | 76kDa |
| 同義語: | ABCG8, GBD4, STSL |
| バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. |
| UniProt Protein Function: | ABCG8: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries. Defects in ABCG8 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter Chromosomal Location of Human Ortholog: 2p21 Cellular Component: apical plasma membrane; plasma membrane; ATP-binding cassette (ABC) transporter complex; receptor complex Molecular Function:protein binding; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding Biological Process: response to drug; negative regulation of cholesterol absorption; cholesterol homeostasis; cholesterol absorption; phospholipid transport; cholesterol efflux; excretion; transmembrane transport; response to nutrient; sterol transport Disease: Sitosterolemia; Gallbladder Disease 4 |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H221 |
| NCBI GenInfo Identifier: | 17432916 |
| NCBI Gene ID: | 64241 |
| NCBI Accession: | Q9H221.1 |
| UniProt Secondary Accession: | Q9H221,Q9DBM0, P58428, |
| UniProt Related Accession: | Q9H221 |
| Molecular Weight: | 673 |
| NCBI Full Name: | ATP-binding cassette sub-family G member 8 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family G (WHITE), member 8 |
| NCBI Official Symbol: | ABCG8 |
| NCBI Official Synonym Symbols: | GBD4; STSL |
| NCBI Protein Information: | ATP-binding cassette sub-family G member 8; sterolin 2; sterolin-2; ATP-binding cassette, subfamily G, member 8 |
| UniProt Protein Name: | ATP-binding cassette sub-family G member 8 |
| UniProt Synonym Protein Names: | Sterolin-2 |
| Protein Family: | ABC transporter G family |
| UniProt Gene Name: | ABCG8 |
| UniProt Entry Name: | ABCG8_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using ABCG8 antibody (CAB1880). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of HeLa cells using ABCG8 antibody (CAB1880) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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