| バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. |
| UniProt Protein Function: | ABCG1: Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, ABC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; recycling endosome; intracellular membrane-bound organelle; mitochondrion; integral to plasma membrane; plasma membrane; endosome; external side of plasma membrane Molecular Function:protein dimerization activity; protein binding; protein homodimerization activity; phospholipid transporter activity; protein heterodimerization activity; cholesterol transporter activity; toxin transporter activity; cholesterol binding; phospholipid binding; sterol-transporting ATPase activity; ADP binding; ATP binding Biological Process: cholesterol metabolic process; detection of hormone stimulus; response to high density lipoprotein stimulus; positive regulation of cholesterol biosynthetic process; intracellular cholesterol transport; cholesterol efflux; lipoprotein metabolic process; response to lipid; response to organic substance; amyloid precursor protein catabolic process; cholesterol homeostasis; reverse cholesterol transport; regulation of transcription, DNA-dependent; phospholipid efflux; transmembrane transport; phospholipid homeostasis |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P45844 |
| NCBI GenInfo Identifier: | 17433715 |
| NCBI Gene ID: | 9619 |
| NCBI Accession: | P45844.3 |
| UniProt Secondary Accession: | P45844,Q86SU8, Q96L76, Q9BXK6, Q9BXK7, Q9BXK8, Q9BXK9 Q9BXL0, Q9BXL1, Q9BXL2, Q9BXL3, Q9BXL4, |
| UniProt Related Accession: | P45844 |
| Molecular Weight: | 86,628 Da |
| NCBI Full Name: | ATP-binding cassette sub-family G member 1 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family G (WHITE), member 1 |
| NCBI Official Symbol: | ABCG1 |
| NCBI Official Synonym Symbols: | ABC8; WHITE1 |
| NCBI Protein Information: | ATP-binding cassette sub-family G member 1; ABC transporter 8; homolog of Drosophila white; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; white protein homolog (ATP-binding cassette transporter 8) |
| UniProt Protein Name: | ATP-binding cassette sub-family G member 1 |
| UniProt Synonym Protein Names: | ATP-binding cassette transporter 8; White protein homolog |
| Protein Family: | ABC transporter G family |
| UniProt Gene Name: | ABCG1 |
| UniProt Entry Name: | ABCG1_HUMAN |
