Anti-ABCE1 Antibody (CAB9135)
- SKU:
- CAB9135
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-ABCE1 Antibody |
| 抗体コード: | CAB9135 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human ABCE1 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, HT-29, K-562, Mouse liver, Mouse spleen, Mouse pancreas |
| 免疫原: | A synthesized peptide derived from human ABCE1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6059 |
| Uniprot: | P61221 |
| セルラーロケーション: | |
| 計算された分子量: | 67kDa |
| 観察された分子量: | 67KDa |
| 同義語: | ABC38, OABP, RLI, RLI1, RNASEL1, RNASELI, RNS4I |
| バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q31 Cellular Component: mitochondrion; membrane; cytoplasm Molecular Function:ATPase activity; iron-sulfur cluster binding; ribonuclease inhibitor activity; ATP binding Biological Process: viral reproduction; response to virus; RNA catabolic process; negative regulation of catalytic activity |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61221 |
| NCBI GenInfo Identifier: | 108773784 |
| NCBI Gene ID: | 6059 |
| NCBI Accession: | NP_001035809.1 |
| UniProt Secondary Accession: | P61221,O88793, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10 Q99K66, |
| UniProt Related Accession: | P61221 |
| Molecular Weight: | Calculated: 67kDaObserved: 67kDa |
| NCBI Full Name: | ATP-binding cassette sub-family E member 1 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family E (OABP), member 1 |
| NCBI Official Symbol: | ABCE1 |
| NCBI Official Synonym Symbols: | RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI |
| NCBI Protein Information: | ATP-binding cassette sub-family E member 1 |
| UniProt Protein Name: | ATP-binding cassette sub-family E member 1 |
| UniProt Synonym Protein Names: | 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I |
| Protein Family: | ABC transporter E family |
| UniProt Gene Name: | ABCE1 |
| UniProt Entry Name: | ABCE1_HUMAN |
 | Western blot - ABCE1 Rabbit mAb (CAB9135) |
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