Anti-ABCD3 Antibody (CAB18177)
- SKU:
- CAB18177
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-ABCD3 Antibody |
抗体コード: | CAB18177 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human ABCD3. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HepG2, Mouse liver, Mouse kidney, Rat liver |
免疫原: | Recombinant protein of human ABCD3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5825 |
Uniprot: | P28288 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 70KDa |
同義語: | ABC43, CBAS5, PMP70, PXMP1, ZWS2, ABCD3 |
バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, ABC family; Transporter; Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 1p21.3 Cellular Component: peroxisomal membrane; peroxisomal matrix; membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane; peroxisome; cytosol Molecular Function:protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding Biological Process: fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; peroxisome organization and biogenesis; transmembrane transport Disease: Bile Acid Synthesis Defect, Congenital, 5 |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P28288 |
NCBI GenInfo Identifier: | 130358 |
NCBI Gene ID: | 5825 |
NCBI Accession: | P28288.1 |
UniProt Related Accession: | P28288 |
Molecular Weight: | 70kDa |
NCBI Full Name: | ATP-binding cassette sub-family D member 3 |
NCBI Synonym Full Names: | ATP binding cassette subfamily D member 3 |
NCBI Official Symbol: | ABCD3 |
NCBI Official Synonym Symbols: | ZWS2; ABC43; CBAS5; PMP70; PXMP1 |
NCBI Protein Information: | ATP-binding cassette sub-family D member 3 |
UniProt Protein Name: | ATP-binding cassette sub-family D member 3 |
UniProt Synonym Protein Names: | 70 kDa peroxisomal membrane protein; PMP70 |
UniProt Gene Name: | ABCD3 |
UniProt Entry Name: | ABCD3_HUMAN |