Anti-ABCC6 Antibody (CAB8100)
- SKU:
- CAB8100
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | ABCC6 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8100 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | mouse liver, rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AIAE MGSY QELL QRKG ALVC LLDQ ARQP GDRG EGET EPGT STKD PRGT SAGR RPEL RRER SIKS VPEK DRTT SEAQ TEVP LDDP DRAG WPAG KDSI QYGR VKAT VHLA YLR |
| 遺伝子ID: | 368 |
| Uniprot: | O95255 |
| セルラーロケーション: | Basolateral cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Single-pass membrane protein |
| 計算された分子量: | 10kDa/95kDa/164kDa |
| 観察された分子量: | 164kDa |
| 同義語: | ABCC6, ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7 |
| バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. |
| UniProt Protein Function: | ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. |
| UniProt Protein Details: | Protein type:Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Chromosomal Location of Human Ortholog: 16p13.11 Cellular Component: nucleus; plasma membrane Molecular Function:anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity Biological Process: response to drug; transmembrane transport; transport Disease: Arterial Calcification, Generalized, Of Infancy, 2; Pseudoxanthoma Elasticum; Pseudoxanthoma Elasticum, Forme Fruste |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95255 |
| NCBI GenInfo Identifier: | 118582251 |
| NCBI Gene ID: | 368 |
| NCBI Accession: | NP_001072996.1 |
| UniProt Secondary Accession: | O95255,P78420, Q8TCY8, Q9UMZ7, A2RRN8, A8KIG6, A8Y988 E7ESW8, |
| UniProt Related Accession: | O95255 |
| Molecular Weight: | 165 kDa |
| NCBI Full Name: | URG7 protein isoform 2 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily C member 6 |
| NCBI Official Symbol: | ABCC6 |
| NCBI Official Synonym Symbols: | ARA; PXE; MLP1; MRP6; PXE1; URG7; ABC34; GACI2; MOATE; MOAT-E; EST349056 |
| NCBI Protein Information: | multidrug resistance-associated protein 6; URG7 protein |
| UniProt Protein Name: | Multidrug resistance-associated protein 6 |
| UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 6; Anthracycline resistance-associated protein; Multi-specific organic anion transporter E; MOAT-E |
| UniProt Gene Name: | ABCC6 |
 | Western blot analysis of extracts of various cell lines, using ABCC6 antibody (CAB8100) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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