Anti-ABCA2 Antibody (CAB16735)
- SKU:
- CAB16735
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ABCA2 Antibody |
| 抗体コード: | CAB16735 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2307-2466 of human ABCA2 (NP_997698.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2307-2466 of human ABCA2 (NP_997698.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FGDG YMIT VRTK SSQS VKDV VRFF NRNF PEAM LKER HHTK VQYQ LKSE HISL AQVF SKME QVSG VLGI EDYS VSQT TLDN VFVN FAKK QSDN LEQQ ETEP PSAL QSPL GCLL SLLR PRSA PTEL RALV ADEP EDLD TEDE GLIS FEEE RAQL SFNT DTLC |
| 遺伝子ID: | 20 |
| Uniprot: | Q9BZC7 |
| セルラーロケーション: | Endosome membrane, Lysosome membrane, Multi-pass membrane protein |
| 計算された分子量: | 230kDa/269kDa |
| 観察された分子量: | 270KDa |
| 同義語: | ABCA2, ABC2 |
| バックグラウンド: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter Chromosomal Location of Human Ortholog: 9q34 Cellular Component: cytoplasmic membrane-bound vesicle; endosome; integral to membrane; lysosome; membrane; microtubule organizing center Molecular Function:ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances Biological Process: cholesterol efflux; cholesterol homeostasis; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus |
| NCBI Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZC7 |
| NCBI GenInfo Identifier: | 206729923 |
| NCBI Gene ID: | 20 |
| NCBI Accession: | Q9BZC7.3 |
| UniProt Secondary Accession: | Q9BZC7,Q5SPY5, Q5W9G5, Q76MW7, Q9HC28, A6NED5, |
| UniProt Related Accession: | Q9BZC7 |
| Molecular Weight: | 269,988 Da |
| NCBI Full Name: | ATP-binding cassette sub-family A member 2 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily A member 2 |
| NCBI Official Symbol: | ABCA2 |
| NCBI Official Synonym Symbols: | ABC2 |
| NCBI Protein Information: | ATP-binding cassette sub-family A member 2 |
| UniProt Protein Name: | ATP-binding cassette sub-family A member 2 |
| UniProt Synonym Protein Names: | ATP-binding cassette transporter 2; ATP-binding cassette 2 |
| Protein Family: | ABC transporter A family |
| UniProt Gene Name: | ABCA2 |
| UniProt Entry Name: | ABCA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ABCA2 Polyclonal Antibody (CAB16735) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
 | Immunofluorescence analysis of U-251 MG cells using ABCA2 Rabbit pAb (CAB16735) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse brain using ABCA2 Rabbit pAb (CAB16735) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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