Anti-4-1BBL/CD137L Antibody (CAB10202)
- SKU:
- CAB10202
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-4-1BBL/CD137L Antibody |
| 抗体コード: | CAB10202 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-254 of human 4-1BBL/CD137L (NP_003802.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-1080, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-254 of human 4-1BBL/CD137L (NP_003802.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VSGA RASP GSAA SPRL REGP ELSP DDPA GLLD LRQG MFAQ LVAQ NVLL IDGP LSWY SDPG LAGV SLTG GLSY KEDT KELV VAKA GVYY VFFQ LELR RVVA GEGS GSVS LALH LQPL RSAA GAAA LALT VDLP PASS EARN SAFG FQGR LLHL SAGQ RLGV HLHT EARA RHAW QLTQ GATV LGLF RVTP EIPA GLPS PRSE |
| 遺伝子ID: | 8744 |
| Uniprot: | P41273 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 26kDa |
| 同義語: | TNFSF9, 4-1BB-L, CD137L, TNLG5A |
| バックグラウンド: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. |
| UniProt Protein Function: | TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: plasma membrane Molecular Function:receptor binding; tumor necrosis factor receptor superfamily binding Biological Process: apoptosis; cell proliferation; cell-cell signaling; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; signal transduction; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] |
| UniProt Code: | P41273 |
| NCBI GenInfo Identifier: | 728739 |
| NCBI Gene ID: | 8744 |
| NCBI Accession: | P41273.1 |
| UniProt Secondary Accession: | P41273,Q2M3S2, |
| UniProt Related Accession: | P41273 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 9 |
| NCBI Synonym Full Names: | TNF superfamily member 9 |
| NCBI Official Symbol: | TNFSF9 |
| NCBI Official Synonym Symbols: | CD137L; TNLG5A; 4-1BB-L |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 9 |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 9 |
| UniProt Synonym Protein Names: | 4-1BB ligand; 4-1BBL |
| Protein Family: | Tumor necrosis factor ligand superfamily |
| UniProt Gene Name: | TNFSF9 |
 | Western blot analysis of extracts of various cell lines, using 4-1BBL/CD137L antibody (CAB10202) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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