Anti-14-3-3 gamma Antibody (CAB9162)
- SKU:
- CAB9162
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-14-3-3 gamma Antibody |
| 抗体コード: | CAB9162 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human 14-3-3 gamma |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, A-431, NIH/3T3, Jurkat, Mouse liver, Mouse heart, Rat lung |
| 免疫原: | A synthesized peptide derived from human 14-3-3 gamma |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 7532 |
| Uniprot: | P61981 |
| セルラーロケーション: | |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 28KDa |
| 同義語: | 14-3-3GAMMA, PPP1R170 |
| バックグラウンド: | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | 14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane Molecular Function:insulin-like growth factor receptor binding; protein binding; protein kinase C binding Biological Process: G2/M transition of mitotic cell cycle; regulation of neuron differentiation; regulation of synaptic plasticity |
| NCBI Summary: | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61981 |
| NCBI GenInfo Identifier: | 48428721 |
| NCBI Gene ID: | 7532 |
| NCBI Accession: | P61981.2 |
| UniProt Secondary Accession: | P61981,O70457, P35214, Q6FH52, Q9UDP2, Q9UN99, |
| UniProt Related Accession: | P61981 |
| Molecular Weight: | 28,303 Da |
| NCBI Full Name: | 14-3-3 protein gamma |
| NCBI Synonym Full Names: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma |
| NCBI Official Symbol: | YWHAG |
| NCBI Official Synonym Symbols: | PPP1R170; 14-3-3GAMMA |
| NCBI Protein Information: | 14-3-3 protein gamma |
| UniProt Protein Name: | 14-3-3 protein gamma |
| UniProt Synonym Protein Names: | Protein kinase C inhibitor protein 1; KCIP-1 |
| Protein Family: | 14-3-3 protein |
| UniProt Gene Name: | YWHAG |
| UniProt Entry Name: | 1433G_HUMAN |
 | Western blot - 14-3-3 gamma Rabbit mAb (CAB9162) |
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