| バックグラウンド: | This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | 14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus; cytosol Molecular Function:protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of protein amino acid dephosphorylation; positive regulation of catalytic activity; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein heterooligomerization; apoptosis; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; cytoplasmic sequestering of protein; innate immune response; gene expression; vascular endothelial growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; protein targeting |
| NCBI Summary: | This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31946 |
| NCBI GenInfo Identifier: | 1345590 |
| NCBI Gene ID: | 7529 |
| NCBI Accession: | P31946.3 |
| UniProt Secondary Accession: | P31946,A8K9K2, E1P616, |
| UniProt Related Accession: | P31946 |
| Molecular Weight: | 246 |
| NCBI Full Name: | 14-3-3 protein beta/alpha |
| NCBI Synonym Full Names: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
| NCBI Official Symbol: | YWHAB |
| NCBI Official Synonym Symbols: | HS1; GW128; YWHAA; KCIP-1; HEL-S-1 |
| NCBI Protein Information: | 14-3-3 protein beta/alpha; 14-3-3 alpha; protein 1054; epididymis secretory protein Li 1; brain protein 14-3-3, beta isoform; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide |
| UniProt Protein Name: | 14-3-3 protein beta/alpha |
| UniProt Synonym Protein Names: | Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1 |
| Protein Family: | 14-3-3 protein |
| UniProt Gene Name: | YWHAB |
| UniProt Entry Name: | 1433B_HUMAN |
