ANO6 Antibody, HRP conjugated (PACO59098)
- SKU:
- PACO59098
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ANO6 Antibody, HRP conjugated (PACO59098) |
抗体コード: | PACO59098 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Anoctamin-6 protein (12-100AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
シノニム: | Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F), ANO6, TMEM16F |
UniProt Protein Function: | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
NCBI Summary: | This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
UniProt Code: | Q4KMQ2 |
NCBI GenInfo Identifier: | 218156299 |
NCBI Gene ID: | 196527 |
NCBI Accession: | NP_001020527.2 |
UniProt Secondary Accession: | Q4KMQ2,Q8N3Q2, A6NNM6, B9EGG0, E7ENK4, E9PB30, E9PCT2 |
UniProt Related Accession: | Q4KMQ2 |
Molecular Weight: | 108,102 Da |
NCBI Full Name: | anoctamin-6 isoform a |
NCBI Synonym Full Names: | anoctamin 6 |
NCBI Official Symbol: | ANO6 |
NCBI Official Synonym Symbols: | SCTS; BDPLT7; TMEM16F |
NCBI Protein Information: | anoctamin-6 |
UniProt Protein Name: | Anoctamin-6 |
UniProt Synonym Protein Names: | Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F |
Protein Family: | Anoctamin |
UniProt Gene Name: | ANO6 |