ANO2 Antibody, Biotin conjugated (PACO57551)
- SKU:
- PACO57551
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ANO2 Antibody, Biotin conjugated (PACO57551) |
抗体コード: | PACO57551 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Anoctamin-2 protein (1-83AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. |
シノニム: | Anoctamin-2 (Transmembrane protein 16B), ANO2, C12orf3 TMEM16B |
UniProt Protein Function: | ANO2: Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, ion channel; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: nucleoplasm; nonmotile primary cilium; plasma membrane Molecular Function:protein homodimerization activity; intracellular calcium activated chloride channel activity; protein heterodimerization activity Biological Process: transmembrane transport |
NCBI Summary: | ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011] |
UniProt Code: | Q9NQ90 |
NCBI GenInfo Identifier: | 262527528 |
NCBI Gene ID: | 57101 |
NCBI Accession: | Q9NQ90.2 |
UniProt Secondary Accession: | Q9NQ90,Q9H847, C4N787, |
UniProt Related Accession: | Q9NQ90 |
Molecular Weight: | 1003 |
NCBI Full Name: | Anoctamin-2 |
NCBI Synonym Full Names: | anoctamin 2, calcium activated chloride channel |
NCBI Official Symbol: | ANO2 |
NCBI Official Synonym Symbols: | C12orf3; TMEM16B |
NCBI Protein Information: | anoctamin-2; transmembrane protein 16B (eight membrane-spanning domains) |
UniProt Protein Name: | Anoctamin-2 |
UniProt Synonym Protein Names: | Transmembrane protein 16B |
Protein Family: | Anoctamin |
UniProt Gene Name: | ANO2 |
UniProt Entry Name: | ANO2_HUMAN |