ANGPT2 Antibody (PACO14032)
- SKU:
- PACO14032
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ANGPT2 Antibody (PACO14032) |
抗体コード: | PACO14032 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human ANGPT2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14032(ANGPT2 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 80 μg, Lane: Mouse kidney tissue, Primary antibody: PACO14032(ANGPT2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14032(ANGPT2 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. |
シノニム: | angiopoietin 2 |
UniProt Protein Function: | ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: extracellular space; cell projection; extracellular region; plasma membrane; nucleus Molecular Function:protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding Biological Process: Tie receptor signaling pathway; organ regeneration; maternal process involved in pregnancy; signal transduction; negative regulation of blood vessel endothelial cell migration; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; response to radiation; negative regulation of angiogenesis; positive regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration |
NCBI Summary: | The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15123 |
NCBI GenInfo Identifier: | 12229555 |
NCBI Gene ID: | 285 |
NCBI Accession: | O15123.1 |
UniProt Secondary Accession: | O15123,Q9NRR7, Q9P2Y7, A0AV38, A8K205, B7ZLM7, |
UniProt Related Accession: | O15123 |
Molecular Weight: | 56,848 Da |
NCBI Full Name: | Angiopoietin-2 |
NCBI Synonym Full Names: | angiopoietin 2 |
NCBI Official Symbol: | ANGPT2 |
NCBI Official Synonym Symbols: | ANG2; AGPT2 |
NCBI Protein Information: | angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a |
UniProt Protein Name: | Angiopoietin-2 |
UniProt Gene Name: | ANGPT2 |
UniProt Entry Name: | ANGP2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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