| UniProt Protein Function: | This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P03971 |
| NCBI GenInfo Identifier: | 313104218 |
| NCBI Gene ID: | 268 |
| NCBI Accession: | P03971.3 |
| UniProt Secondary Accession: | P03971,O75246, Q6GTN3, |
| UniProt Related Accession: | P03971 |
| Molecular Weight: | |
| NCBI Full Name: | Muellerian-inhibiting factor |
| NCBI Synonym Full Names: | anti-Mullerian hormone |
| NCBI Official Symbol: | AMH |
| NCBI Official Synonym Symbols: | MIF; MIS |
| NCBI Protein Information: | muellerian-inhibiting factor |
| UniProt Protein Name: | Muellerian-inhibiting factor |
| UniProt Synonym Protein Names: | Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS |
| Protein Family: | Muellerian-inhibiting factor |
| UniProt Gene Name: | AMH |
