ALOX12B Antibody, Biotin conjugated (PACO62226)
- SKU:
- PACO62226
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ALOX12B Antibody, Biotin conjugated (PACO62226) |
抗体コード: | PACO62226 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acid, generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid, to (12R)-hydroperoxyeicosatetraenoic acid, (12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. |
シノニム: | Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11) (Epidermis-type lipoxygenase 12), ALOX12B |
UniProt Code: | O75342 |
NCBI GenInfo Identifier: | 4502053 |
NCBI Gene ID: | 242 |
NCBI Accession: | NP_001130.1 |
UniProt Related Accession: | O75342 |
Molecular Weight: | 80,356 Da |
NCBI Full Name: | arachidonate 12-lipoxygenase, 12R-type |
NCBI Synonym Full Names: | arachidonate 12-lipoxygenase, 12R type |
NCBI Official Symbol: | ALOX12B |
NCBI Official Synonym Symbols: | ARCI2; 12R-LOX |
NCBI Protein Information: | arachidonate 12-lipoxygenase, 12R-type; 12R-lipoxygenase; epidermis-type lipoxygenase 12 |
UniProt Protein Name: | Arachidonate 12-lipoxygenase, 12R-type |
UniProt Synonym Protein Names: | Epidermis-type lipoxygenase 12 |
Protein Family: | Arachidonate 12-lipoxygenase |
UniProt Gene Name: | ALOX12B |
UniProt Entry Name: | LX12B_HUMAN |