ALKBH2 Antibody (PACO43424)
- SKU:
- PACO43424
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ALKBH2 Antibody (PACO43424) |
抗体コード: | PACO43424 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human DNA oxidative demethylase ALKBH2 protein (1-261AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO43424 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43424 at dilution of 1:100. |
バックグラウンド: | Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. |
シノニム: | DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1), ALKBH2, ABH2 |
UniProt Protein Function: | ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage; EC 1.14.11.33; Oxidoreductase; Hydrolase; Demethylase Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity Biological Process: DNA dealkylation; DNA repair |
NCBI Summary: | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6NS38 |
NCBI GenInfo Identifier: | 74736661 |
NCBI Gene ID: | 121642 |
NCBI Accession: | Q6NS38.1 |
UniProt Related Accession: | Q6NS38 |
Molecular Weight: | |
NCBI Full Name: | DNA oxidative demethylase ALKBH2 |
NCBI Synonym Full Names: | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
NCBI Official Symbol: | ALKBH2 |
NCBI Official Synonym Symbols: | ABH2 |
NCBI Protein Information: | DNA oxidative demethylase ALKBH2 |
UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 |
UniProt Synonym Protein Names: | Alkylated DNA repair protein alkB homolog 2; DNA oxidative demethylase ALKBH2; Oxy DC1 |
Protein Family: | Alkane 1-monooxygenase |
UniProt Gene Name: | ALKBH2 |
UniProt Entry Name: | ALKB2_HUMAN |
Antibodies |
Anti-ALKBH2 Antibody (CAB6340) |
Secondary Antibody |
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