UniProt Protein Function: | JTV1: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.Chromosomal Location of Human Ortholog: 7p22Cellular Component: membrane; cytosol; nucleusMolecular Function: protein bindingBiological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; apoptosis; positive regulation of protein ubiquitination; gene expression |
UniProt Protein Details: | |
NCBI Summary: | The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13155 |
NCBI GenInfo Identifier: | 12644405 |
NCBI Gene ID: | 7965 |
NCBI Accession: | Q13155.2 |
UniProt Secondary Accession: | Q13155,Q75MR1, Q96CZ5, Q9P1L2 |
UniProt Related Accession: | Q13155 |
Molecular Weight: | 35,349 Da |
NCBI Full Name: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
NCBI Synonym Full Names: | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
NCBI Official Symbol: | AIMP2 |
NCBI Official Synonym Symbols: | P38; JTV1; JTV-1; PRO0992 |
NCBI Protein Information: | aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38 |
UniProt Protein Name: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
UniProt Synonym Protein Names: | Multisynthase complex auxiliary component p38; Protein JTV-1 |
Protein Family: | Aminoacyl tRNA synthase complex-interacting multifunctional protein |
UniProt Gene Name: | AIMP2 |
UniProt Entry Name: | AIMP2_HUMAN |