バックグラウンド: | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1. When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion. Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression. |
シノニム: | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2), AHCYL1, DCAL IRBIT XPVKONA |
NCBI Summary: | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
UniProt Code: | O43865 |
NCBI GenInfo Identifier: | 109731743 |
NCBI Gene ID: | 9628 |
NCBI Accession: | BC113572 |
UniProt Secondary Accession: | O43865,O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6 Q8TE13, Q8TE14, Q8TE15, C9JE95, F8W7W5, |
UniProt Related Accession: | P49758 |
Molecular Weight: | 53,319 Da |
NCBI Full Name: | Homo sapiens regulator of G-protein signaling 6, mRNA |
NCBI Synonym Full Names: | regulator of G-protein signaling 6 |
NCBI Official Symbol: | RGS6 |
NCBI Official Synonym Symbols: | GAP; S914; HA117 |
NCBI Protein Information: | regulator of G-protein signaling 6 |
UniProt Protein Name: | Putative adenosylhomocysteinase 2 |
UniProt Synonym Protein Names: | DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | AHCYL1 |
UniProt Entry Name: | SAHH2_HUMAN |