AGXT Antibody (PACO54638)
- SKU:
- PACO54638
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | AGXT Antibody (PACO54638) |
抗体コード: | PACO54638 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Serine--pyruvate aminotransferase protein (112-294AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate. All lanes: AGXT antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO54638 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO54638 at dilution of 1:100. |
バックグラウンド: | intracellular membrane-bounded organelle, peroxisomal matrix, peroxisome, alanine-glyoxylate transaminase activity, amino acid, binding, protein homodimerization activity, protein self-association, pyridoxal phosphate binding, receptor binding, serine-pyruvate transaminase activity |
シノニム: | Serine--pyruvate aminotransferase (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44), AGXT, AGT1 SPAT |
UniProt Protein Function: | AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.51; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Motility/polarity/chemotaxis; EC 2.6.1.44 Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: peroxisomal matrix; peroxisome Molecular Function:alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; proteasomal protein catabolic process Disease: Hyperoxaluria, Primary, Type I |
NCBI Summary: | This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21549 |
NCBI GenInfo Identifier: | 134855 |
NCBI Gene ID: | 189 |
NCBI Accession: | P21549.1 |
UniProt Secondary Accession: | P21549,Q53QU6, |
UniProt Related Accession: | P21549 |
Molecular Weight: | 43010 Da |
NCBI Full Name: | Serine--pyruvate aminotransferase |
NCBI Synonym Full Names: | alanine-glyoxylate aminotransferase |
NCBI Official Symbol: | AGXT |
NCBI Official Synonym Symbols: | AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1 |
NCBI Protein Information: | serine--pyruvate aminotransferase |
UniProt Protein Name: | Serine--pyruvate aminotransferase |
UniProt Synonym Protein Names: | Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT |
Protein Family: | Serine--pyruvate aminotransferase |
UniProt Gene Name: | AGXT |
UniProt Entry Name: | SPYA_HUMAN |