AFF4 Antibody, Biotin conjugated (PACO47217)
- SKU:
- PACO47217
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | AFF4 Antibody, Biotin conjugated (PACO47217) |
抗体コード: | PACO47217 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human AF4/FMR2 family member 4 protein (77-334AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
シノニム: | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein), AFF4, AF5Q31 MCEF |
UniProt Protein Function: | MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm; transcription elongation factor complex; mitochondrion; nucleolus; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; spermatid development Disease: Chops Syndrome |
NCBI Summary: | The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011] |
UniProt Code: | Q9UHB7 |
NCBI GenInfo Identifier: | 74720814 |
NCBI Gene ID: | 27125 |
NCBI Accession: | Q9UHB7.1 |
UniProt Related Accession: | Q9UHB7 |
Molecular Weight: | |
NCBI Full Name: | AF4/FMR2 family member 4 |
NCBI Synonym Full Names: | AF4/FMR2 family member 4 |
NCBI Official Symbol: | AFF4 |
NCBI Official Synonym Symbols: | MCEF; CHOPS; AF5Q31 |
NCBI Protein Information: | AF4/FMR2 family member 4 |
UniProt Protein Name: | AF4/FMR2 family member 4 |
UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein |
Protein Family: | AF4/FMR2 family |
UniProt Gene Name: | AFF4 |
UniProt Entry Name: | AFF4_HUMAN |