AEN Antibody, HRP conjugated (PACO38047)
- SKU:
- PACO38047
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | AEN Antibody, HRP conjugated (PACO38047) |
抗体コード: | PACO38047 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. |
シノニム: | Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1), AEN, ISG20L1 |
UniProt Protein Function: | AEN: Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.-.-; Hydrolase; Nucleolus; Apoptosis Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: nucleoplasm; nuclear membrane; nucleolus; nucleus Molecular Function:nucleic acid binding; exonuclease activity Biological Process: response to ionizing radiation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
UniProt Code: | Q8WTP8 |
NCBI GenInfo Identifier: | 194239666 |
NCBI Gene ID: | 64782 |
NCBI Accession: | NP_073604.3 |
UniProt Secondary Accession: | Q8WTP8,Q9BSA5, Q9H9X7, C9J571, |
UniProt Related Accession: | Q8WTP8 |
Molecular Weight: | 36,496 Da |
NCBI Full Name: | apoptosis-enhancing nuclease |
NCBI Synonym Full Names: | apoptosis enhancing nuclease |
NCBI Official Symbol: | AEN |
NCBI Official Synonym Symbols: | ISG20L1; pp12744 |
NCBI Protein Information: | apoptosis-enhancing nuclease; interferon-stimulated 20 kDa exonuclease-like 1; interferon stimulated exonuclease gene 20kDa-like 1 |
UniProt Protein Name: | Apoptosis-enhancing nuclease |
UniProt Synonym Protein Names: | Interferon-stimulated 20 kDa exonuclease-like 1 |
Protein Family: | Apoptosis-enhancing nuclease |
UniProt Gene Name: | AEN |
UniProt Entry Name: | AEN_HUMAN |