ADIPOR1 Antibody, FITC conjugated (PACO48212)
- SKU:
- PACO48212
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | ADIPOR1 Antibody, FITC conjugated (PACO48212) |
抗体コード: | PACO48212 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Adiponectin receptor protein 1 protein (1-63AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid, oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). |
シノニム: | Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I), ADIPOR1, PAQR1 TESBP1A |
UniProt Protein Function: | ADIPOR1: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Belongs to the ADIPOR family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: membrane; plasma membrane; integral to membrane Molecular Function:adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity; protein kinase binding Biological Process: hormone-mediated signaling; adiponectin-mediated signaling pathway; positive regulation of JAK-STAT cascade; fatty acid oxidation; negative regulation of cell growth; positive regulation of insulin receptor signaling pathway; leptin-mediated signaling pathway |
NCBI Summary: | This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014] |
UniProt Code: | Q96A54 |
NCBI GenInfo Identifier: | 38372248 |
NCBI Gene ID: | 51094 |
NCBI Accession: | Q96A54.1 |
UniProt Secondary Accession: | Q96A54,Q53HS7, Q53YY6, Q9Y360, B3KMB0, |
UniProt Related Accession: | Q96A54 |
Molecular Weight: | 375 |
NCBI Full Name: | Adiponectin receptor protein 1 |
NCBI Synonym Full Names: | adiponectin receptor 1 |
NCBI Official Symbol: | ADIPOR1 |
NCBI Official Synonym Symbols: | CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A |
NCBI Protein Information: | adiponectin receptor protein 1; progestin and adipoQ receptor family member I |
UniProt Protein Name: | Adiponectin receptor protein 1 |
UniProt Synonym Protein Names: | Progestin and adipoQ receptor family member I |
Protein Family: | Adiponectin receptor protein |
UniProt Gene Name: | ADIPOR1 |
UniProt Entry Name: | ADR1_HUMAN |