ADCY6 Antibody, Biotin conjugated (PACO54629)
- SKU:
- PACO54629
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ADCY6 Antibody, Biotin conjugated (PACO54629) |
抗体コード: | PACO54629 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Adenylate cyclase type 6 protein (9-118AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli (By similarity). |
シノニム: | Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase), ADCY6, KIAA0422 |
UniProt Protein Function: | ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.Protein type: Nucleotide Metabolism - purine; EC 4.6.1.1; Transporter; Lyase; Adenylyl cyclase; Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integralChromosomal Location of Human Ortholog: 12q12-q13Cellular Component: membrane; plasma membrane; integral to membrane; ciliumMolecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activityBiological Process: epidermal growth factor receptor signaling pathway; synaptic transmission; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; dopamine receptor signaling pathway; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; transmembrane transport; G-protein signaling, adenylate cyclase activating pathwayDisease: Lethal Congenital Contracture Syndrome 8 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43306 |
NCBI GenInfo Identifier: | 12644065 |
NCBI Gene ID: | 112 |
NCBI Accession: | O43306.2 |
UniProt Secondary Accession: | O43306,Q9NR75, Q9UDB0 |
UniProt Related Accession: | O43306 |
Molecular Weight: | |
NCBI Full Name: | Adenylate cyclase type 6 |
NCBI Synonym Full Names: | adenylate cyclase 6 |
NCBI Official Symbol: | ADCY6 |
NCBI Official Synonym Symbols: | AC6 |
NCBI Protein Information: | adenylate cyclase type 6; ATP pyrophosphate-lyase 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase |
UniProt Protein Name: | Adenylate cyclase type 6 |
UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase |
Protein Family: | Adenylate cyclase |
UniProt Gene Name: | ADCY6 |
UniProt Entry Name: | ADCY6_HUMAN |