ADAMTS5 Antibody, FITC conjugated (PACO59551)
- SKU:
- PACO59551
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | ADAMTS5 Antibody, FITC conjugated (PACO59551) |
抗体コード: | PACO59551 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 5 protein (535-646AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu- |-Ala-393' site, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
シノニム: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2), ADAMTS5, ADAMTS11 ADMP2 |
UniProt Protein Function: | ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region Molecular Function:integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification |
NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q9UNA0 |
NCBI GenInfo Identifier: | 317373326 |
NCBI Gene ID: | 11096 |
NCBI Accession: | Q9UNA0.2 |
UniProt Related Accession: | Q9UNA0 |
Molecular Weight: | |
NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
NCBI Official Symbol: | ADAMTS5 |
NCBI Official Synonym Symbols: | ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11 |
NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
UniProt Synonym Protein Names: | A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2 |
UniProt Gene Name: | ADAMTS5 |
UniProt Entry Name: | ATS5_HUMAN |