UniProt Protein Function: | ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8p11.22 Cellular Component: extracellular space; focal adhesion; cell surface; basolateral plasma membrane; cytoplasm; integral to membrane Molecular Function:integrin binding; collagen binding; protein binding; protein kinase C binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; laminin binding; SH3 domain binding Biological Process: integrin-mediated signaling pathway; positive regulation of keratinocyte migration; extracellular matrix organization and biogenesis; activation of MAPKK activity; cell-matrix adhesion; response to glucocorticoid stimulus; membrane protein ectodomain proteolysis; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; response to manganese ion; keratinocyte differentiation; collagen catabolic process; extracellular matrix disassembly; PMA-inducible membrane protein ectodomain proteolysis; monocyte activation; response to hydrogen peroxide; positive regulation of protein secretion; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; response to calcium ion; cell adhesion Disease: Cone-rod Dystrophy 9 |
NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q13443 |
NCBI GenInfo Identifier: | 24211441 |
NCBI Gene ID: | 8754 |
NCBI Accession: | Q13443.1 |
UniProt Secondary Accession: | Q13443,Q10718, Q8NFM6, B7ZLN7, |
UniProt Related Accession: | Q13443 |
Molecular Weight: | 72,359 Da |
NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 9 |
NCBI Synonym Full Names: | ADAM metallopeptidase domain 9 |
NCBI Official Symbol: | ADAM9 |
NCBI Official Synonym Symbols: | MCMP; MDC9; CORD9; Mltng |
NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 9; cone rod dystrophy 9; myeloma cell metalloproteinase; cellular disintegrin-related protein; ADAM metallopeptidase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9 |
UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 9 |
UniProt Synonym Protein Names: | Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase |
Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
UniProt Gene Name: | ADAM9 |
UniProt Entry Name: | ADAM9_HUMAN |