UniProt Protein Function: | ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis. |
UniProt Protein Details: | Protein type:Protease; Membrane protein, integral; EC 3.4.24.-; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q26 Cellular Component: nucleoplasm; mitochondrion; integral to membrane; plasma membrane; extracellular region Molecular Function:protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; SH3 domain binding Biological Process: epidermal growth factor receptor signaling pathway; proteolysis; cell adhesion; myoblast fusion |
NCBI Summary: | This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014] |
UniProt Code: | O43184 |
NCBI GenInfo Identifier: | 229463008 |
NCBI Gene ID: | 8038 |
NCBI Accession: | O43184.3 |
UniProt Secondary Accession: | O43184,O60470, Q5JRP0, Q5JRP1, Q6P9E3, Q6UWB0, |
UniProt Related Accession: | O43184 |
Molecular Weight: | 909 |
NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 12 |
NCBI Synonym Full Names: | ADAM metallopeptidase domain 12 |
NCBI Official Symbol: | ADAM12 |
NCBI Official Synonym Symbols: | MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1 |
NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane |
UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 12 |
UniProt Synonym Protein Names: | Meltrin-alpha |
Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
UniProt Gene Name: | ADAM12 |
UniProt Entry Name: | ADA12_HUMAN |