UniProt Protein Function: | DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, Duffy family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: 1q21-q22Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine productionDisease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16570 |
NCBI GenInfo Identifier: | 67476970 |
NCBI Gene ID: | 2532 |
NCBI Accession: | Q16570.3 |
UniProt Secondary Accession: | Q16570,O75898, Q16300, Q8WWE3, Q9UJP0, Q9UKZ5, Q9UKZ6 Q9UQE1, A8YPG5 |
UniProt Related Accession: | Q16570 |
Molecular Weight: | 35,678 Da |
NCBI Full Name: | Atypical chemokine receptor 1 |
NCBI Synonym Full Names: | atypical chemokine receptor 1 (Duffy blood group) |
NCBI Official Symbol: | ACKR1 |
NCBI Official Synonym Symbols: | FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1 |
NCBI Protein Information: | atypical chemokine receptor 1; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; Duffy blood group, chemokine receptor; Duffy blood group, atypical chemokine receptor |
UniProt Protein Name: | Atypical chemokine receptor 1 |
UniProt Synonym Protein Names: | Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234 |
Protein Family: | Darcynin |
UniProt Gene Name: | ACKR1 |
UniProt Entry Name: | ACKR1_HUMAN |