ACD Antibody (PACO58332)
- SKU:
- PACO58332
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ACD Antibody (PACO58332) |
抗体コード: | PACO58332 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Adrenocortical dysplasia protein homolog protein (328-497AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse spleen tissue. All lanes: ACD antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa. |
バックグラウンド: | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. |
シノニム: | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein), ACD, PIP1 PTOP TINT1 TPP1 |
UniProt Protein Function: | ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm Molecular Function:protein binding; telomeric DNA binding Biological Process: intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; telomere assembly; telomere capping; telomere maintenance Disease: Dyskeratosis Congenita, Autosomal Dominant 6 |
NCBI Summary: | This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96AP0 |
NCBI GenInfo Identifier: | 296439451 |
NCBI Gene ID: | 65057 |
NCBI Accession: | Q96AP0.3 |
UniProt Secondary Accession: | Q96AP0,Q562H5, Q9H8F9, |
UniProt Related Accession: | Q96AP0 |
Molecular Weight: | 58kDa |
NCBI Full Name: | Adrenocortical dysplasia protein homolog |
NCBI Synonym Full Names: | ACD, shelterin complex subunit and telomerase recruitment factor |
NCBI Official Symbol: | ACD |
NCBI Official Synonym Symbols: | PIP1; PTOP; TPP1; TINT1 |
NCBI Protein Information: | adrenocortical dysplasia protein homolog |
UniProt Protein Name: | Adrenocortical dysplasia protein homolog |
UniProt Synonym Protein Names: | POT1 and TIN2-interacting protein |
Protein Family: | ACD11 homolog protein |
UniProt Gene Name: | ACD |
Antibodies | ELISA Kits |
Anti-ACD Antibody (CAB12177) | Human ACD (Adrenocortical Dysplasia Homolog) ELISA Kit (HUES01487) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |