ABR Antibody, FITC conjugated (PACO54120)
- SKU:
- PACO54120
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | ABR Antibody, FITC conjugated (PACO54120) |
抗体コード: | PACO54120 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Active breakpoint cluster region-related protein (797-859AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. |
シノニム: | Active breakpoint cluster region-related protein, ABR |
UniProt Protein Function: | ABR: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs, Rac/Rho; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); GAPs; ATYPICAL group; BCR family Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: membrane; plasma membrane; cytosol Molecular Function:Rho guanyl-nucleotide exchange factor activity; GTPase activator activity Biological Process: inner ear morphogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; response to lipopolysaccharide; negative regulation of neutrophil degranulation; regulation of small GTPase mediated signal transduction; positive regulation of phagocytosis; small GTPase mediated signal transduction; negative regulation of inflammatory response; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; negative regulation of cell migration Disease: Medulloblastoma |
NCBI Summary: | This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q12979 |
NCBI GenInfo Identifier: | 531034789 |
NCBI Gene ID: | 29 |
NCBI Accession: | NP_001269078.1 |
UniProt Secondary Accession: | Q12979,Q13693, Q13694, B3KW89, B7Z6H7, D3DTH3, D3DTH4 F5H3S2, F5H8B3, |
UniProt Related Accession: | Q12979 |
Molecular Weight: | 92,425 Da |
NCBI Full Name: | active breakpoint cluster region-related protein isoform e |
NCBI Synonym Full Names: | active BCR-related |
NCBI Official Symbol: | ABR |
NCBI Official Synonym Symbols: | MDB |
NCBI Protein Information: | active breakpoint cluster region-related protein |
UniProt Protein Name: | Active breakpoint cluster region-related protein |
Protein Family: | Active breakpoint cluster region-related protein |
UniProt Gene Name: | ABR |
UniProt Entry Name: | ABR_HUMAN |