ABCG5 Antibody (PACO56434)
- SKU:
- PACO56434
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ABCG5 Antibody (PACO56434) |
抗体コード: | PACO56434 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human ATP-binding cassette sub-family G member 5 protein (1-127AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: ABCG5 antibody at 8.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 73, 29 kDa. Observed band size: 73 kDa. | |
IHC image of PACO56434 diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO56434 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. |
シノニム: | ATP-binding cassette sub-family G member 5 (Sterolin-1), ABCG5 |
UniProt Protein Function: | ABCG5: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Defects in ABCG5 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2p21 Cellular Component: apical plasma membrane; plasma membrane; ATP-binding cassette (ABC) transporter complex; receptor complex Molecular Function:protein binding; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding Biological Process: response to drug; negative regulation of cholesterol absorption; cholesterol homeostasis; cholesterol absorption; cholesterol efflux; response to ionizing radiation; excretion; transmembrane transport; response to nutrient; sterol transport Disease: Sitosterolemia |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H222 |
NCBI GenInfo Identifier: | 17432917 |
NCBI Gene ID: | 64240 |
NCBI Accession: | Q9H222.1 |
UniProt Secondary Accession: | Q9H222,Q99PE8, |
UniProt Related Accession: | Q9H222 |
Molecular Weight: | 28,480 Da |
NCBI Full Name: | ATP-binding cassette sub-family G member 5 |
NCBI Synonym Full Names: | ATP-binding cassette, sub-family G (WHITE), member 5 |
NCBI Official Symbol: | ABCG5 |
NCBI Official Synonym Symbols: | STSL |
NCBI Protein Information: | ATP-binding cassette sub-family G member 5; sterolin 1; sterolin-1; ATP-binding cassette, subfamily G, member 5 |
UniProt Protein Name: | ATP-binding cassette sub-family G member 5 |
UniProt Synonym Protein Names: | Sterolin-1 |
Protein Family: | ABC transporter G family |
UniProt Gene Name: | ABCG5 |
UniProt Entry Name: | ABCG5_HUMAN |
Antibodies |
Anti-ABCG5 Antibody (CAB8589) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |