AADAC Antibody (PACO15213)
- SKU:
- PACO15213
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | AADAC Antibody (PACO15213) |
抗体コード: | PACO15213 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Fusion protein of human AADAC |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15213(AADAC Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue, Human liver cancer tissue, Primary antibody: PACO15213(AADAC Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15213(AADAC Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens. Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acid, derived from hydrolysis of newly formed triglyceride stores. |
シノニム: | Arylacetamide deacetylase |
UniProt Protein Function: | AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family. |
UniProt Protein Details: | Protein type:Deacetylase; Endoplasmic reticulum; Motility/polarity/chemotaxis; Lipase; Membrane protein, integral; EC 3.1.1.3 Chromosomal Location of Human Ortholog: 3q25.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity Biological Process: xenobiotic metabolic process |
NCBI Summary: | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008] |
UniProt Code: | P22760 |
NCBI GenInfo Identifier: | 317373587 |
NCBI Gene ID: | 13 |
NCBI Accession: | P22760.5 |
UniProt Secondary Accession: | P22760,Q8N1A9, A8K3L3, D3DNJ6, |
UniProt Related Accession: | P22760 |
Molecular Weight: | 45,734 Da |
NCBI Full Name: | Arylacetamide deacetylase |
NCBI Synonym Full Names: | arylacetamide deacetylase |
NCBI Official Symbol: | AADAC |
NCBI Official Synonym Symbols: | DAC; CES5A1 |
NCBI Protein Information: | arylacetamide deacetylase |
UniProt Protein Name: | Arylacetamide deacetylase |
Protein Family: | Arylacetamide deacetylase |
UniProt Gene Name: | AADAC |
UniProt Entry Name: | AAAD_HUMAN |