AADAC Antibody, HRP conjugated (PACO24673)
- SKU:
- PACO24673
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | AADAC Antibody, HRP conjugated (PACO24673) |
抗体コード: | PACO24673 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Arylacetamide deacetylase protein (24-399AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acid, derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. |
シノニム: | Arylacetamide deacetylase (EC 3.1.1.3), AADAC, DAC |
UniProt Protein Function: | AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family. |
UniProt Protein Details: | Protein type:Deacetylase; Endoplasmic reticulum; Motility/polarity/chemotaxis; Lipase; Membrane protein, integral; EC 3.1.1.3 Chromosomal Location of Human Ortholog: 3q25.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity Biological Process: xenobiotic metabolic process |
NCBI Summary: | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008] |
UniProt Code: | P22760 |
NCBI GenInfo Identifier: | 317373587 |
NCBI Gene ID: | 13 |
NCBI Accession: | P22760.5 |
UniProt Secondary Accession: | P22760,Q8N1A9, A8K3L3, D3DNJ6, |
UniProt Related Accession: | P22760 |
Molecular Weight: | 45,734 Da |
NCBI Full Name: | Arylacetamide deacetylase |
NCBI Synonym Full Names: | arylacetamide deacetylase |
NCBI Official Symbol: | AADAC |
NCBI Official Synonym Symbols: | DAC; CES5A1 |
NCBI Protein Information: | arylacetamide deacetylase |
UniProt Protein Name: | Arylacetamide deacetylase |
Protein Family: | Arylacetamide deacetylase |
UniProt Gene Name: | AADAC |
UniProt Entry Name: | AAAD_HUMAN |